Mechanobiology - Mechanisms of force sensation and transduction that control cell behavior in health and disease.

Amsterdam, March 22-24, 2016.

Cellular mechanotransduction occurs in protein complexes that physically couple the extracellular matrix (through integrins) or neighboring cells (through cadherins) to the intracellular cytoskeleton. This allows cells to sense, modulate, and respond to the mechanical properties of their surrounding environment. In cells the information is integrated with signals derived from growth factors to tune gene expression patterns and thereby controlling growth, motility and differentiation.

The Mechanobiology 2016 meeting will explore the latest insights in mechanotransduction at sites of integrin- and cadherin-mediated adhesion. One session will focus on the key signaling pathways affected by physical cues from the environment. Deregulation of mechanosensing as underlying mechanism for diseases such as cancer, heart failure, and fibrosis will be addressed. Further, time is allotted to learn about recent advances in the exploitation of matrix mechanics for stem cell differentiation programming, regenerative medicine, and organ-on-chip applications.

Presentations from key scientists in the field are combined with shorter talks selected from submitted abstracts. In addition, there will be ample of time allotted for posters and informal discussions.